Depends on what you want the default action to be when they reopen Google Chrome, if you want it to ALWAYS launch to that singular homepage, keep the existing settings, and teach your users the magic of CTRL+Shift+T (opens recently closed tabs).

If you want to make the home button take them to the home page, configure the GPO:

Step 2: Change your homepage to Google In the Appearance section, click the button next to Show Home button, then click the blue link Change. Delete the text in the box, which is either about. In this video we show you how to make ANY website your homepage. HelpCloud is your Go-To Tech Resolution Hub. Our search engine offers answers with resolut. To change the homepage in Google Chrome, go to Settings → Appearance. In the section labeled “Show Home button,” you can set the homepage to either an empty Tab or a website URL that you designate. If the Home button is missing from the Chrome toolbar.

To change the Action on Start-up to be Restore Last Session

Open Google Chrome, then select the three, vertical dots next to the profile icon. Select Settings, then under Appearance, turn the toggle for Show home button to on. Choose the option you'd like to use: New Tab page or Enter custom web address. Open Firefox, then select the three, horizontal lines next to the profile icon. Google allows users to search the Web for images, news, products, video, and other content.

This will let you set the home page.

Go to Google Chrome->Homepage->Configure Home page

*I haven't tested it*

Automatically Make Google My Homepage

You could try setting the Restore Last Session, and have the URLS to OPEN on startup with your homepage, it might do both.